Endocrine Abstracts

Adrenocorticotropic hormone (ACTH) adenomas causing Cushing’s disease (CD) have been recognized as an aggressive and invasive subtype of pituitary adenomas. Remission of CD without surgical or medical treatment is an extremely rare occurrence. Moreover, a clinically relevant peculiarity of these tumors, though rarely observed, is their ability to modify their clinical expression from a silent form to CD or vice versa, the latter even more unexpected. We describe the case ...

IntroductionLung Neuroendocrine tumors (NETs) range in aggressiveness from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to the high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). TC have excellent prognosis post-surgery and European Neuroendocrine Tumor Society (ENETS) recommands no adjuvant therapy for these well diferentiated tumors.Case report<p clas...

Introduction: Chronic kidney disease (CKD) is associated with alterations in endogenous glucocorticoid regulation through various mechanisms: longer plasma cortisol half-life, reduced renal cortisol clearance, loss of 11b-HSD type 2 activity in the kidney contributing to an elevated cortisol/cortisone ratio, less effective hepatic metabolism of cortisol and, finally, hyperactivation of the hypothalamus-pituitary-adrenal axis due to acidosis, chronic stress, and inflammation.</...

Introduction: Craniopharyngiomas are rare tumors which are typically located in the sellar and suprasellar region. They can be solid or mixed, cystic-epithelial. Treatment options include surgery, radiation or intracystic therapy. Adipsic diabetes insipidus is a rare, life-threatening disease which can sometimes be associated with craniopharyngioma, either because of tumor mass effect, or as a postprocedure complication. Ultimately, this can cause severe hypernatremia, so long...

Introduction: Congenital ichthyoses are a group of inherited keratinization disorders that pose a challenge in terms of diagnosis, treatment, and clinical associations with other pathologies. The association with vitamin D deficiency and possible bone changes is cited, but the exact mechanism of occurrence of endocrine pathologies is not described.Case report: We report the case of a 16-year-old teenage boy known to have congenital ichthyosis, having bee...

Introduction: Pituitary Stalk Interruption Syndrome (PSIS) is a congenital developmental anomaly affecting the pituitary gland. Characterized by a triad of features including a thin or absent pituitary stalk, adenohypophysis hypoplasia, and ectopic neurohypophysis on MRI, PSIS can lead to isolated or combined pituitary hormone deficiency. Symptoms may manifest at various life stages, with 70% of cases identified in childhood due to growth retardation. Notably, some patients ex...

Introduction: Testotoxicosis, also known as familial male limited precocious puberty, is a rare cause of peripheral precious puberty caused by an activating mutation of the gene encoding for the LH receptor on Leydig cells (LHCGR gene, cr2p21). This causes autonomous testosterone production irrespective of prepubertal LH values. Ultimately, this can cause psychosocial complications; advanced bone age and low adult height; as well as central precocious puberty.<p class="abs...

Background: Renal dysfunction is known to be more prevalent amongst patients with obesity. Metabolic and bariatric surgery is associated with positive renal effects through intricate pathways. We aimed to determine the short-term impact of laparoscopic sleeve gastrectomy (LSG) on renal function and to identify parameters associated with its variation.Materials and methods: We performed a retrospective study on 268 patients (115 males and 153 females) eva...

Objective: To evaluate the comparative effects of different glucocorticoid treatments on growth and sexual maturation in patients with congenital adrenal hyperplasia.Patients and methods: We conducted a retrospective observational cohort study in 78 patients (60 girls, 18 boys) diagnosed with congenital adrenal hyperplasia (CAH), followed-up for a period of 5 years. The majority had 21-hydroxylase deficiency (75 patients), 2 had 11-β hydroxylase def...

Thyroid carcinoma is the most common endocrine malignancy and represents ~1% of all types of human cancer.Objective: As the molecular pathogenesis of thyroid cancer still remains to be clarified, the goal of our study was to find new molecular markers that could improve the diagnostics, follow-up protocols, treatment outcome, prognosis and the quality of life of differentiated thyroid cancer patients.Subjects and methods: Matched t...